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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13078 | Tankyrase-IN-2 | Wnt/beta-catenin | |
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively | |||
T63508 | OM-153 | ||
OM-153 is a potent inhibitor of tankyrase, acting on tankyrase 1 (IC50: 13 nM) and tankyrase 2 (IC50: 2 nM), and inhibiting WNT/β-linked protein signaling and proliferation in COLO 320DM. | |||
T72922 | TNKS1/2-IN-1 | ||
TNKS1/2-IN-1 is a potent inhibitor of tankyrase (TNKS1/2), exhibiting pIC50 values between 7.1-8.2. It is utilized in research targeting cancer, fibrosis, and other hyperproliferative diseases. | |||
T69955 | JPI-547 HCl | ||
JPI 547, also known as NOV 1402, is an oral inhibitor of PARP 1/2 and Tankyrase 1/2. JPI-547 demonstrated anti-tumor activity in BRCA-deficient xenograft models as a single-agent and in combination with chemotherapy and ... | |||
T70138 | AZ0108 | ||
AZ0108 is an orally bioavailable, potent PARP1,2,6 inhibitor that potently inhibits centrosome clustering and is suitable for in vivo efficacy and tolerability studies. AZ0108 has been utilized as in vitro tools and in ... |